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Plant-derived extracellular vesicles -a novel clinical anti-inflammatory drug carrier worthy of investigation

(117) proposed that the degeneration of spinal components is associated with gut microbiota anomalies and separately categorized osteoporosis, synovial osteoarthritis, disc degeneration, spinal sarcopenia, and lumbar stenosis under spinal degenerative diseases (SDD), introducing the concept of the gutspine axis for the first time

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For certain lipogenic genes, however, the reversal of downregulated expression was not complete (Fig